yes, 10 hours....bc you need to level up you and your innocent devils bc Isaac is followed by a stronger enemy with no time to heal...get a corpsey, a battle type innonect devil, although easy to get, he is REALLY strong...when you get a battle ID use only axe untill he evolves, then only sword to the final evolution.
you can skip a lot of things making the game even 6 hours or so...go only for what matters...focus on being stronger.i made a speed run for that game (i do for all cv's) and i got 1 hour and 57 minutes...but don't think you can get as near that (at least not for a first run, hell at least for a 50's runs).
item combination faq so you don't waste rare material on a shitty "bamboo thingy"
http://www.gamefaqs.com/console/ps2/file/925894/42170also don't worry for maps for the game is quite rly lined up...
also in the forest of Jigramunt, don't go to the tower you see there, and even not to the tower followed by it...it's not worthy you'll lose too much time, efforts, frustation (too long) and possibly die (at least at the second tower)
after all said, have fun, it's a great game i love it, LoI had a cool story, but this one has better graphics better jogability, cool weapons...i have a thing for the dragon killer sword see the faq how to make it, it's not so far in the game till you can make it and it's rly destructable. with it and a corpsey battle ID, you are invincible.
farewell my son.
edit evolving to corpsey you no longer need to use sword you can use any weapon.the combo light, light, strong, it's the best sometimes hit more than longer ones is quick, dont let your guard down, use the dodge thingy wildly.that's all you can beat it easilly with mah recumendationz!!!!!!!!!!!for trully i'm a cv master guider!!!!!