Those are really good ideas well - there is definitely a lot of potential in an original IP version!
As for the Dr Fraken games - yeah, they are a pretty frustrating series. They're more like early computer games, with their cryptic clues and hard to decipher mapping. Frankenstein: The Monster Returns is a lot of fun, though - you should check it out if you get the chance.
For some sci-fi/werewolf/Island of Dr Moreua type action, Werewolf: The Last Warrior and WolfChild are pretty good too, IMO - in both you control a werewolf that can change between human and more powerful werewolf forms while trying to stop a mad scientist from taking over the world. The setting of WolfChild is a straight-up Dr Moreua inspired island stronghold.