I never got around to playing Lords of Shadow 2, one of the reasons being that when I first saw the trailer, I really disliked all of the sci-fi elements I was seeing. I was expecting the traditional haunting atmosphere of the Castlevania games, and instead I was watching footage of some futuristic lab and killer robots.
The atmosphere and setting of the Castlevania games has always been a fundamental part of the experience for me, so I would't want to see it switch over to sci-fi.