I predict that Konami will unfortunately not be making an HD 2D Cv any time soon, as they don't want to steal any thunder from LoS as a series.
That is unless they do a side story either placed in between LoS and it's sequel, or a prequel that details how Zobek managed to get Gabriel to wear the devilmask in he first place.
If Konami does decide to do something, WayForward absolutely MUST be put in charge of it. I thank Iga for his devotion and years of service to the series, but he's shown that as far as Cv is concerned he's hit a creative wall (some would argue that this happened long ago). It's time to make a way forward for someone new to make a 2D Castlevania, based on the LoS universe.