while 2.5d is nice, i will always love traditional hi-res sprites more. hand-drawn sprites just have that special charm to them; from the fluid animations of alucard in symphony, to literally seeing soma's cold breath in dawn, amongst many many other details that, while possible to achieve with 2.5d, still wont be quite the same
call me oldschool but i love the clashing effects 2D sprites have with 3D parallax backgrounds, such as the rotating background corridor in that 1 section in super castlevania iv, the 3D chapel with the Great Sword spirit floating in the middle of the room in Symphony.
seeing stuff like this still impresses me till this day, and i will miss that feeling