I like Curse of Darkness. I thought the fighting system was fun, despite looking a little more brutish when compared to Lament of Innocence.
I thought that Isaac was phenomenal, the story was told well, and Germain kicked ass.
Crisis, you obviously didn't do everything in that game, because it took me months to make every enemy, every weapon, level up to 99, and beat the game with Trevor with 100% completion on every map.
Granted, I'm a lunatic for doing so, but even still, it should have taken you about a week and a half if you invested a few hours a day and still did a solid amount of the worthwhile things.
I loved the Nuculais battle.