Ignoring the obvious fact that is an Alternate Universe Lords of Shadow 2 had a big amount of Sci-Fi elements: A bioengineered virus that mutates people into gun wielding monsters, riot police riding flying mechas, and probably more stuff I forgot already.
and in my opinion they kinda took the spotlight from the magic and fantasy elements, something important in a Castlevania title to me.
I personally like the Sci-Fi elements, but restricted to sections like Frankenstein's laboratories, in the same way Clock Punk is usually rectricted to the Castle's Clocktower, allowing the game to have more variety.