I'm sure it has nothing to do with the game because it's based on European mythology, but in Japan four is also the number of death and it's extremly taboo to have things arranged in fours.

Also here's another flower symbolism from The Dracula X Chronicles I thought of. This was from the cover of the game:

It shows the three main character Dracula, Richter, and Maria. Maria is standing at the bottom surrounded by four flowers and holding a small cross. The cross I think is symbolic of her dove weapons, as doves are a symbol of God in Christianity. The four flowers, like the bouque she holds in her full body sketch, represent the four animals she has control over: the cardinals, the cat, the turtle, and the dragon. I think the white flowers represent the cat (which is actually a baby white tiger), the red flowers represent the cardinals, the blue flowers represent the turtle, and the black flowers represent the dragon. These four animals are actually based on Chinese Constellations, and I'm sure each one is represented by it's own element. I'm pretty sure that the cardinals are fire (as they can turn into a pheonix and shoot fireballs), and the turtle is water. The tiger is most likely earth because it's a land animal and the dragon might be air because it has wings and flies.