I might get bashed for saying it, but I wouldn't mind seeing Ninja Theory take a stab at Castlevania next. It wouldn't be a huge jump to make after MercurySteam, and NT already went through a remarkably parallel scenario with DmC. Just like LoS, I shunned DmC for months before finally trying it and ended up enjoying it. But also like LoS, it drew heavy criticism from fans despite its glowing reviews, and their Japanese-to-Western-development leap was largely identical.
Still, this is a recurring scenario in recent years. I bash sequels and reboots for crapping on the nostalgia of their IPs, then eventually try them (usually because they're in the bargain bin, on a Steam sale, or just because other gamers tell me I should), and I end up having to eat some of my words. It's hard not to be that way with long-running classics, from Castlevania and Final Fantasy to Devil May Cry and Tomb Raider, but I guess we have to accept that games are a constant evolution and cannot hope to maintain the consistency of other entertainment media.
I should probably just stop being an elitist pre-judgmental a'hole and enjoy the entries we get... as long as they don't suck goblin balls.
Besides, Ninja Theory places its focus on characters and plot development, with strong cinematic styling that could serve Castlevania well. And so far, I've enjoyed most of their releases. I'd be just as happy with a fresh 2D/2.5D outing, but it's an option.