There really isn't anything to suggest that Castlevania will be severing ties with Nintendo in the near future. The series has a long history with Nintendo handhelds, and Mirror of Fate's poor reception is nowhere near as significant as to prevent the franchise from returning to the 3DS. Console-wise, Castlevania already has three heavy-weight installments running on Sony systems, so the PS3/X360 choice for LoS is completely trivial.
Neobelmont:
But that's just the thing; a classically-inspired Castlevania would struggle to gain any form of mainstream appeal, since what made classic CV great no longer figures on the list of qualities modern gamers look for. If you need convincing, just read through reviews for the excellent DXC -- you'll find it a consensus among reviewers that the gameplay is too dated, difficult, or frustrating for the current gaming demographic (of which the reviewers themselves are members). You see, we've been so spoiled by years of technical and conceptual overhauls that many of us can no longer appreciate what made old-school gaming so popular. It's a real shame, but it's something we need to accept: unamended classic CV has no true future.
Beowulf:
That's all very nice, but you haven't really explained anything. What you're essentially telling us is that we should welcome any game into the series, so long as it has the name "Castlevania" slapped onto it and bears something remotely close to a gothic atmosphere -- but that's not how these kinds of matters are settled. Inccubus has pointed it out already: we all have different ideas about what "the world of Castlevania" is, so telling us that 'anything goes' really doesn't help. Besides, our general conception of Castlevania isn't limited to canonity; it's assorted with a whole mess of ideas concerning gameplay, design, atmosphere, and overall presence that can't be so easily reduced to one all-inclusive 'Castlevania world'.
And to clear matters up, DCW remains an exploitable time slot in which a future Castlevania game can be slated. We can be as pessimistic as we like, but it's far from being just a legend.