For Bloodlines, it is fantastic, but I never really play it. Hell, I've played The Adventure more than it (not saying adventure is better  

, far from it). The controls are tight and responsive as hell, but there's something about moving John and Eric that I don't like. I can't place my finger on it, but their walking and jumps, plus their sprites seem a bit spastic. Plus, John's tiny head in proportion to the gigantic fucking arms always bugged me and seems goofy, but thats just me. I also didn't like how the whip was slower while crouched, which is more realistic, but again that's just me.
I still have an absolute blast playing, and I get used to the above issues rather quickly, but that might be one reason I don't play it as much. With the adventure I guess it's so simple and barebones I put up with its MUCH more flawed design (one reason I like Valis 1 for Genesis). 
Another thing I absolutely dig in Bloodlines is its focus on horror and gore. Rondo, Dawn and PoR pissed me off (judgement was at least a spinoff) in that they ditched the horror and Gothic nature. I can't stand the overt anime style in them (In a bit of a hypocrite here cus I like the style in Legends,  it I guess because it reminds me more of Manwha than Manga or Anime, plus the lack of cutscenes makes you forget about its artstyle a bit). Bloodlines did carry on the fantastic attention to detail in its horror set pieces, such as the leadup to the boss of the Verseilles Palace, which was fucking awesome!
Besides that I HATE the tricky bits, like the multiple broken off layers part in the final stage. 
I think I need to play Bloodlines more to get a better feel for it, And hopefully change my mind on the issues I mentioned above. Besides that, it does have one of my favorite CV songs, Iron Blue Intention.
Last thing I'll say: CV4 may seem like an extra step in a sequel sense of us because of the name, but it IS a remaketo the Japanese audience, and just called Akumajo Dracula again. Sure, later games do take ideas from CV4, like Slogra and Gaiben, the whip twirling, the swinging, and attacking in multiple direction in a more restricted sense, but perhaps the game doesn't seem like such a big deal to the country who produced the games for ages, because it's essentially the same idea as Akumajo Dracula X68000/Chronicles, which nobody makes a big deal about in terms of fanfare (even tho we all agree its a fantastic game) and references are limited to a few enemies and sprites for later games. Maybe what I'm saying is it doesn't stand out as much to the Japanese, because there are so many Akumajo Draculas with the same story. It won't stand out as much as Akumajo Densetsu or Vampire Killer. And the games sales, which I've heard on wikipedia so take that with a grain of salt, were only modest. But marketing it as a sequel was a better move for US and PAL regions.