This has been an idea that was roaming my brain for quite a while: What if Castlevania had a Sci-Fi setting?
Here's how i thing it would be: Doctor Mathias Akula Cronqvist was once a human who was a genius in Bio-engineering who modified his own DNA strains to, in his own twisted mind `evolve`, into something far greater, thus becoming: Dracula!
Simon Belmont would technically be Master Chief wielding a Plasma Whip.
Death, well, he would be still Dr. Akula's eternal buddy (Untill the Demon Castle War of 1999), but he would more be Drakula's first Bio-engineered patient that went horribly wrong, he then ressurected him and gave him Psychokinetic abilities, thus making D34TH the `technically-living` walking/floating corpse he is.
The bosses of Castlevania 1? Dr. Akula's bio-engineered patients that have been heavily modified to the genetic level.
But that's my take for a Sci-Fi Castlevania, i'm more intrested in what would be your take for a Sci-Fi Castlevania be. =)