Since MoF is an interquel, I guess that means that it'll be the spiritual retelling of CV3 with Trevor and Al. So I imagine Sypha and Grant will be there too, which will explain the co-op. And then we'll have Lords 2, which will be Simon hunting down Gabriel. So, we'll have our retelling of CV1/SCIV/Chronicles/Haunted Castle/Captain N.
I wonder if they'll cover any of the games past that. A MercurySteam Juste Belmont would certainly be something.