Yes, it seems as though after SotN he is just after destruction pure and simple. He just doesn't care about anything anymore. It's as if he's had a psychotic break or something. He has literally gone from revenge to just because I can. Although he seems calm on the surface, he is likely nothing more than someone who craves destruction almost like Kefka from FF6 (just not outwardly insane). All this after SotN. Beforehand, he would just await in his throne room for the "hero" and simply fight to the death, or he would use some insidious plot like with Christopher's son or what he did in RoB/DXC. We never see that after SotN. Not only that, but he seems to take pleasure in dealing with intruders as well. In PoR, he just writes off Jonathan and Charlotte and in OoE, when Shanoa says that she will kill him, he says that he hasn't danced in ages. He was never that arrogant before SotN.
It just seems like after he heard what Lisa's last words were, anything left of humanity and attachments disappeared leaving only that thirst for destruction. Makes me wonder how he would react to Alucard in the 1999 event (something we will probably never know).