Mmh, I don't know how much gym practice you have, but it's easy to see how JohnnyBoy's pecs are way too elongated and pronounced. If those are pecs, they're Schwarzenegger's pecs on the body of a guy of average muscolar tone. And the pose doesn't help. I agree that it's an optical illusion, but if you told me that character is a girl, I wouldn't have flinched.
In fact, when I opened that page I went "that's some wildly inaccurate version of Sonia an... oh snap". I swear. It's clearly a case of Kojima going overboard and making a character that stops being a feminine man and becomes a masculine girl.
On Julius, I think he looks freakish. It's the beard. He looks like his face (which, aside from the eye design, is markedly masculine) is pasted onto the body. Once again, his pose and proportions are in the "masculine girl" field, the pose is absolutely feminine and the dressing (that scarf, oh that scarf) is wtf material, but the face... it's so odd. I can't exactly point my finger at the issue. It looks like a woman till the nose, then he's got this mouth and beard and those are markedly masculine.
I think I understand why Kojima doesn't draw "masculine" man, because if this is what would come out, it's absolutely freak-ish. And once again, she has her style and it's fine and she's pretty much phenomenal when she does
her thing, but it just falls flat on CV in my opinion (except the SotN stuff, but that works for obvious reasons - Alucard IS a feminine guy and it's absolutely justified being so).
And I don't think the real issue is heart-shaped faces - that's so common in japanese art that identifying it with females is possibly also a limit of my western eyes. It's just that Kojima seems to be either influenced by Riyoko Ikeda for most of her visage designs, or by pre-raphaelite art. Seriously. Look at Richter and Maria's face and then at

She's definitely drawing something from there, but does it fit CV in any shape or form? Not for me, but YMMV.