Marie - Through the concept of belief, what people do not understand, is that Marie did see Gabriel's fate through the mirror, but she did not see her death. Bastarnized and orphaned her son, Trevor to the Brotherhood of "Light". You also must realize, is that she did not 'sacrifice' herself, she was murdered in cold blood through the influence of the Devil's Mask in which was put on Gabriel by Zobek. You must also take into consideration, that in the end: SHE is the reason for Gabriel's downfall, she LIED to him. But no matter how much hate grew in his heart, Gabriel loves her dearly. As the quotation at the end of the game "I know what it is you yearn for.", Zobek is speaking about his wife, that is ALL Dracula wants back, he could give a (pardon my french) fuck less about humanity, god, or Satan. She too forgives Gabriel.
Claudia - Yes, she saw her fate through her psychic powers and that the gauntlet was a key. But again, you must realize that, the very gauntlet itself, again as I have stated over a million times, is the POWER OF DOMINANCE. If you pay strict attention to when Gabriel actually uses it, he absorbs the power of: Carmilia, The Necromancer, TFO. Death had the ability to control Gabriel at the very end through the sheer power of "Dominance". But in the end she, Claudia forgave him, in silence.
Laura - You must take into consideration, that it isn't just her blood, it is in fact the blood of the Dark Lady (The Queen; Carmillia) that Gabriel took in. Purely drinking the "blood" of the innocent. A child like spirit, and or vampire is far more powerful, due to its purity. This is why Gabriel/Dracula turned so quickly and became THE king of Vampires and later The Prince of Darkness.
Take in consideration that: Dracula has 3 wives (Stoker lore) which is why 3 women had been very important.
Sypha - Yeah, she sacrificed herself in order to save Simon's life; but she returns as a Spirit due to being a Belnades. She aids Simon on his quest and what I feel (which really isn't stated) comforts him.
There are also two other women you are forgetting that had been murdered in cold blood -
Malphas (by Gabriel)
Baba-Yoga (who cannot die; Zobek, which he thinks). Baba is also very important in actual lore to a "Mirror of Fate". She is the only one who -CAN- defeat Death.
Two very important witches. Both cursed by Love, both betraying one another, both of which are in fact (in actual real life lore/mythology) are Skinwalkers (Navajo legend)
But, to get off subject - if anyone had paid strict attention to the MoF storyline - The BELMONT clan is NO longer apart of the order (I.e Simon and so on). They sole purpose is to destroy Dracula at any cost due to one thing: vengeance.