Hey man, I've played Otomedius Excellent and it mentions Julius Belmont by name as her big brother.
There's nothing out there that says that game is NOT canon.
Then again, going by 'all appearances', we'd have to start getting to the nitty gritty and deciding which games use characters in alternate universes, that are most certainly, definitely, not canon (Konami Dream TV Mix, Otomedius series, Konami Wai Wai World, Pachislot titles, etc.).