Info taken from a couple interviews conducted by Microsoft and Inside XBox.
https://mixer.com/Xbox?vod=38224649 (starts 3h53m)
https://www.youtube.com/watch?v=jyLsYii7wOE&t Some highlights (and info from the Japanese Twitter feed):
-The man at the beginning of the trailer is none other than Morrison from the DMC anime (seriously, apparently they changed his race) so the anime is indeed canon
-The crux of the city is about a giant demon tree growing in Redgrave City (the city clearly is meant to evoke Dante's old alias Tony Redgrave)
-The demon at the beginning among fountains of blood is of course a major villain. According to Itsuno he's 26 feet tall and according to Twitter he's an emperor of demons
-Like the end of the DMC4 novelization Nero was gifted a Devil May Cry sign by Dante and has opened his own branch of the DMC business. His is mobile, the van being the actual office and even has a reception area.
-The woman with Nero is Nico, a weaponsmith who designed his prosthetic Devil Breaker arms. Her grandmother is Nell Goldstein, a gunsmith. Nell was actually a character in a non-canon novel who designed Ebony & Ivory.
-Nero will acquire several different Devil Breakers throughout the game and they all have different abilities. Ones revealed have abilities similar to the Devil Bringer (the classic Snatch and Buster abilities), another is rocket-infused allowing Nero to it launch at enemies and keep them in a juggled state and he can even ride the rocket like a skateboard, yet another is electricity-infused so he can strike with an electric punch or charge a scatter shot that ricochets around, and yet another gives him the ability to slow enemies. Overall these seem to be the equivalent of Dante's Styles system
-The Breakers deteriorate and Nero replaces them with spares he carries. This doesn't affect gameplay and is just an attention to detail.
-Nero appears to now have a shotgun in his arsenal (60 second mark of the Inside XBox video)
-Sins from DMC3 return
-Playable at GamesCom and will have more info about the Breakers
-There will be an event detailing more of the game on June 20:
https://twitter.com/devilmaycry_jp/status/1007078193529016320 -The theme playing during the trailer is called "Devil Trigger" by Ali Edwards and is now available:
https://twitter.com/DevilMayCry/status/1006581905112883206Its music video has hints to the third playable character (revealed in a leak to be named V)