ya man I totlly agree that vampire shit in 64 was da bomb shame they never used it again since eh
Well, that's probably because those were the only games in which there were vampires as normal enemies. Kind of weird how Dracula is the "Lord of all Vampires" and yet you almost never encounter any aside for maybe one or two bosses per game and in most cases, Dracula is one of the two.
We need that status back and the lycanthropy (werewolf curse) status is a idea with potential. Hell, if a game is made with multiple endings, instead of getting game over when you are consumed by the appropriate status affliction (vamp or lycan), you play from that point on as one of them and get a unique ending. Each would have unique abilities that would change how you play the game. Once infected with either, you would have a certain amount of time to cure yourself. If you run out of time, you are stuck as either a vampire or a werewolf for the rest of the game. Add in the fact time is continuously elapsing like in CV64/LoD, and the gameplay can be further augmented. For example, if you have become a vampire and it's during daylight hours and you go outside, you take damage unless you are in a shady spot.
Add in giving you a choice between multiple characters, you can give each character they own set of immunities and be more vulnerable to other things. For example, the Belmont would have resistance to VAMP because the ritual in LoI that transformed the Whip of Alchemy into the Vampire Killer also made it so that Leon and all of his decedents were resistant to the vampire curse. Another character could be resistant to LYCAN for what ever reason. These ideas could really make the experiences really fun.
These are just my thoughts.