I second VladCT on the Tales series. I'm still not 'done' with it and I actually want to pick up Xillia cause I like how it looks. But I dunno. The battle system in all those games never clicked for me.
Resident Evil is another series I never could get into, except RE4 which I really loved. But the first three, and the last two? I feel nothing playing them. And I got RE1 when it was brand new, so not even nostalgia does it for me. Cause I never cared in the first place. I wish I felt what others felt.
Next up is Advance Wars. I love Fire Emblem but the generic troops in Advance Wars made me not care. I need to care for my troops!
Finally, Smash Bros. I just don't get it.
Honorable mention is the Elder Scrolls games, which I love on paper. But beyond Morrowind (which I actually finished, and loved) I never had fun with the series after that. Oblivion and Skyrim look so sweet but... Again, I just feel...empty.