These days Konami is not what it was in the 90's, they released another hack'n slash game such as LoS and I think this genre is being repetitive and Konami has to change the course of the series.
I would like to play a Witcher 3 - Undead Nightmare mix remake of Simon's Quest since I think W3 is what the SQ playability must be and UN manage the music that good that creates the atmosphere of a survival horror game.
If SQ would have an hypotetical remake then how about remaking Castlevania 1 being a prelude to SQ, just like Konami made with MGS5.
Another interesting remake would be Dracula's Curse playing the same way as Harmony of Despair in 2.5D or sprites/backgrounds, the difference between Harmony of Despair an this remake would be the team work so your teammates depend on you and you on them for healing, shielding, switching weapon in action, reaching points.
So what are yours, maybe someday our wishes will be released...