Honestly, the way Western-developed games in Japanese series tend to go, who knows? I'm not terribly optimistic about the outcome either (as Konami's other outsourced games have done pretty damn poorly, like Contra 4 and the Silent Hills), but it seems like people are more hyped for Lords of Shadow than any Castlevania in recent memory. Kojima's approval of the game and the participation of famous actors like Patrick Stewart certainly didn't hurt, either.
To me, what makes this game stand out is that David Cox is stressing the importance of the game's environment as well as the action, something that IGA's games more often than not completely glaze over. He talks a lot about the game's platforming and slower-paced exploration. Hopefully, these will set Lords apart from your everyday beat-the-crap-out-of-stuff-stylishly action game, but I guess it all boils down to how well it generates hype.